Chronic ulcerative stomatitis and lichen planus: just a coincidence or a direct link between the two diseases?
نویسندگان
چکیده
Chronic ulcerative dermatitis (CUS) is characterized by painful exacerbating and remitting oral erosions and ulcerations. A very characteristic direct immunofluorescence (DIF) pattern differentiates CUS from other immune-mediated oral vesiculo-erosive conditions. The clinical and histopathological features of CUS are very similar to erosive oral lichen planus. A middle-aged woman had CUS confirmed by DIF and chronic plantar ulceration. Histology of the lesion on the sole showed features of lichen planus (LP). DIF of the plantar lesion showed the same pattern as the oral lesion of CUS. The relationship between CUS and erosive (ulcerative) LP of the foot is discussed. Chloroquine improved the oral lesions while oral cyclosporine A ameliorated both oral and plantar lesions.
منابع مشابه
Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa.
OBJECTIVE The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the sera of patients with erosive oral lichen planus and cutaneous lichen planus. METHODS We studied the pre-immune and immune serum of a rabbit immunized with a peptide corresponding to the N-terminus of the 70-kDa antigen chronic ulcerative stomatitis protein; sera from ...
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Chronic ulcerative stomatitis (CUS) is a mucocutaneous disease primarily involving mucosal surfaces, but occasionally may involve the skin. Clinically, CUS patients exhibit erosive or ulcerative lesions of the oral mucosa that resemble erosive oral lichen planus. Direct immunofluorescence (DIF) studies of mucosal or skin biopsies reveal a unique pattern of IgG immunoglobulin bound to nuclei of ...
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